| Title | [Angioneurotic orolingual edema associated with the use of rt-PA following a stroke.] | | Author(s) | Laubinger R, Guthke K, Erdmann U, Klein U | | Institution | Klinik für Anaesthesie und operative Intensivtherapie, Südharz-Krankenhaus, Dr. Robert Koch-Str. 39, 99734, Nordhausen, Deutschland, Raimondo.Laubinger@shk-ndh.de. | | Source | Anaesthesist 2007 Aug 12. | | Abstract | Angioneurotic orolingual edema associated with the use of rt-PA (recombinant tissue plasminogen activator) for systemic thrombolysis are described in the literature, but only as isolated case reports. Strangely, the rate of anaphylactic reactions to rt-PA is higher (1.9%) when they are used in the treatment of acute stroke than when they are given to treat acute myocardial infarction (0.02%). Patients who are taking ACE inhibitors seem to be at increased risk of such a potentially life-threatening event. We now report on two patients, in each of whom asymmetric angioneurotic edema was observed following successful thrombolysis with rt-PA. Both these patients were taking ACE inhibitors. It was possible to avoid intubation and ventilation in both cases. Therapy with ranitidine, clemastine, and a C1 esterase inhibitor resulted in the resolution of symptomatic angioneurotic edema within hours. | | Language | GER | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17694290 |
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